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SPRAVATO® (Esketamine) Treatment

SPRAVATO® is FDA-approved for the treatment of treatment-resistant depression. It is administered under the supervision of a health care provider. SPRAVATO® can be used as monotherapy or can be administered with oral antidepressants.

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Treating Treatment-Resistant Depression

At Comprehensive Minds, we understand the struggles one faces when symptoms of depression are resistant to several medications. We now have an FDA-approved approach for treatment-resistant depression. Esketamine, also known as SPRAVATO®, is not an oral medication that is taken daily. SPRAVATO® can be administered intranasally yourself under the supervision of a healthcare provider.

Understanding How SPRAVATOⓇ Works

Understanding How SPRAVATO® Works

SPRAVATO® is an NMDA receptor antagonist that works on glutamate. The exact mechanism of SPRAVATO® is unknown; however, it is different from traditional antidepressants as it works on glutamate.

Who Can Benefit from SPRAVATO®?

If you have tried two or more antidepressants without relief of the symptoms of depression, then SPRAVATO® may be an option for you. At Comprehensive Minds, you will be evaluated by our experienced providers and your medical and mental health conditions before a recommendation is made.

  • Have tried multiple medications with limited success
  • Experience side effects with antidepressants, limiting their use.
  • Want a more personalized approach to treatment.
How To Track Your Progress With SPRAVATOⓇ

How To Track Your Progress With SPRAVATO®

Some may notice an improvement as soon as a few treatments, while others take a few weeks to show an effect.

Your healthcare provider will monitor your progress using the PHQ-9 questionnaire.

Let your provider know if you have experience with sedation, dissociation, and respiratory depression.

Things To Discuss With My Provider Before Starting SPRAVATO®

  • Discuss all medications you take with your health care provider. These can include all prescriptions, over-the-counter medications, and any supplements and vitamins.
  • Tell your provider if you take any CNS medications, psychostimulants, or monoamine oxidase inhibitors.
  • Discuss all your medical conditions with your provider. If you have heart or brain problems, including:
    • High blood pressure (hypertension)
    • Slow or fast heartbeats that cause shortness of breath, chest pain, lightheadedness, or fainting
    • A history of heart attacks
    • History of stroke
    • Heart valve disease or heart failure
    • History of brain injury or any condition where there is increased pressure in the brain
    • Have liver problems
    • Have psychosis
    • Are pregnant or plan to become pregnant. You should not take SPRAVATO® if you are pregnant.

What to Expect During And After SPRAVATO® Treatment

SPRAVATOⓇ Patient Support And Education

SPRAVATO® Patient Support And Education

SPRAVATO® with me provides support and resources for patients.

  • 1-844-4S-WITHME (1-844-479-4846)
  • Cost support
  • Dedicated Care Navigator
  • Treatment preparation and ongoing support
Download Full SPRAVATO® Patient Information (PDF)

Take the first step toward relief from treatment-resistant depression.

Regain control of your life, rebuild your confidence, and enhance your mental wellness with the compassionate care of our trusted SPRAVATO® specialists in Broadview Heights.

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